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Scientific Object Identifier: http://s-o-i.org/1.1/TAS-09-125-9
DOI: https://dx.doi.org/10.15863/TAS.2023.09.125.9
Language: English
Citation: Shikhaliyev, N. G., et al. (2023). Synthesis of dichlorodiazadienes and hydrozo derivative of ?-ketoether and assessment of their antibacterial activity: crystal structure of (E)-4-((1-(4-(tert-butyl)phenyl)-2,2-dichlorovinyl)diazenyl)benzonitrile (VII). ISJ Theoretical & Applied Science, 09 (125), 132-152. Soi: http://s-o-i.org/1.1/TAS-09-125-9 Doi: https://dx.doi.org/10.15863/TAS.2023.09.125.9 |
Pages: 132-152
Published: 30.09.2023
Abstract: The new dichlorodiazadiene derivatives (I-VIII) and from solvolysis of II compound, which resulted in methyl (Z)-2-(4-(tert-butyl)phenyl)-2-(2-(p-tolyl)hydrazineylidene)acetate (IX) were synthesized, which exhibits a wide range of antimicrobial activity against grampositive and gramnegative bacteria. IX and (E)-1-(1-(4-(tert-butyl)phenyl)-2,2-dichlorovinyl)-2-(4-methoxyphenyl) diazene (III) showed high antimicrobial activity against Acinetobacter baumanii, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus, where the zone of inhibition was 1.3-2.6 and 1.3-2.1 times larger,respectively, compared with gentamicin. This substances have a wide range of inhibitory effect agent of gramnegative and grampositive bacteria and can be used as a disinfectant agent. In the crystal structure of VII, the molecules are connected by C—H?Cl, C---H…N, and C---Cl…( interactions, forming a 3D network.
Key words: dichlorodiazadiene derivatives, antibacterial activity, grampositive and gramnegative bacteria, Hirshfeld surface analysis.
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