ISJ Theoretical & Applied Science 07(51) 2017

ISPC Materials and technologies, Philadelphia, USA

Sujayev A, Najafova R, Hasanli S, Grigoryeva N

REFORMATION OF 1- (N-11, 21-EPITIOPROPYL)-4-PHENYL-5-ACETYL-6-METHYL-l, 2,3,4-TETRAHYDROPYRIMIDINE-2 ONE WITH VARIOUS AMINES.

Full Article: PDF

Scientific Object Identifier: http://s-o-i.org/1.1/TAS-07-51-8

DOI: https://dx.doi.org/10.15863/TAS.2017.07.51.8

Language: English

Citation: Sujayev A, Najafova R, Hasanli S, Grigoryeva N (2017) REFORMATION OF 1- (N-11, 21-EPITIOPROPYL)-4-PHENYL-5-ACETYL-6-METHYL-l, 2,3,4-TETRAHYDROPYRIMIDINE-2 ONE WITH VARIOUS AMINES. ISJ Theoretical & Applied Science, 07 (51): 42-46. Soi: http://s-o-i.org/1.1/TAS-07-51-8 Doi: https://dx.doi.org/10.15863/TAS.2017.07.51.8

Pages: 42-46

Published: 30.07.2017

Abstract: This article is dedicated to the investigation of nucleophilic substitution reactions of 3,4-dihydropyrimidine-2 (1H) ones with 1, 2-epoxy-3-chloropropane, including the synthesis of oxiranes unknown to literature in this way. It has been determined that the nucleophilic substitution reaction occurs due to the active hydrogen atoms in the third situation in pyrimidine ring. At the same time, it was revealed that thione-thiol tautomerism was characteristic of 3,4-dihydropyrimidine-2 (1H) thiones and the reaction goes in thiol form.

Key words: 1, 2-epoxy-3-chloropropane, oxyrane, thione-thiol tautomerism, nucleophilic substitution reaction.