ISJ Theoretical & Applied Science 08(112) 2022

Philadelphia, USA

Azizova, Z. Sh., Musakhodjaeva, D. A., Ruzibakiyeva, M. R., & Ibragimkhodjaev, B. U.

Th-system production imbalance in primary infertility in women and men of Uzbek ethnicity.

Full Article: PDF

Scientific Object Identifier: http://s-o-i.org/1.1/TAS-08-112-28

DOI: https://dx.doi.org/10.15863/TAS.2022.08.112.28

Language: Russian

Citation: Azizova, Z. Sh., Musakhodjaeva, D. A., Ruzibakiyeva, M. R., & Ibragimkhodjaev, B. U. (2022). Th-system production imbalance in primary infertility in women and men of Uzbek ethnicity. ISJ Theoretical & Applied Science, 08 (112), 301-307. Soi: http://s-o-i.org/1.1/TAS-08-112-28 Doi: https://dx.doi.org/10.15863/TAS.2022.08.112.28

Pages: 301-307

Published: 30.08.2022

Abstract: Cytokines play an important role in many processes: the formation of male and female germ cells, fertilization and implantation, the formation of the placenta, growth and development of the embryo. Disturbance of the balance of pro-inflammatory and anti-inflammatory cytokines should be considered as an important pathogenetic link in the development of infertility. Methods: The concentration of pro-inflammatory (IL-6, IL-17А, TNF?) and anti-inflammatory (IL-10) cytokines in blood serum was determined by enzyme-linked immunosorbent assay using test systems of VECTOR-BEST JSC (Russia, Novosibirsk), in accordance with manufacturer's recommendations. Statistical processing of the obtained data was carried out using the computer program Statistica 6.0. The significance of differences in the mean values (P) of the compared indicators was assessed by Student's t-test (t). Results: As a result of a comparative analysis in serum concentrations of IL-6, IL-17A, TNF? and IL-10, a pronounced imbalance was established. Conclusion: The data obtained reflect the imbalance of Th1/Th2/Th17 cytokine production at the systemic level, in particular the reproductive system, where a delicate balance between pro- and anti-inflammatory responses is required, which was disturbed in individuals in our study.

Key words: infertility, men, cytokines, women, immunity.