Full Article: PDF
Scientific Object Identifier: http://s-o-i.org/1.1/TAS-08-124-9
DOI: https://dx.doi.org/10.15863/TAS.2023.08.124.9
Language: English
Citation: Safarova, A. F. (2023). The association between follicular aspiration fluid cytokines and results of in vitro fertilization procedure. ISJ Theoretical & Applied Science, 08 (124), 62-66. Soi: http://s-o-i.org/1.1/TAS-08-124-9 Doi: https://dx.doi.org/10.15863/TAS.2023.08.124.9 |
Pages: 62-66
Published: 30.08.2023
Abstract: The pupose of the study was to investigate the association between the levels of cytokines in follicular aspiration fluid (FAF) and the outcomes of in vitro fertilization (IVF) procedure. Material and Methods: 131 patients were included in the study. They were grouped based on the outcome or parameters of the IVF procedure (successful or not), pregnancy status and female infertility. Cytokines (IL-1?, TNF-a, IFN-?, IL-4, IL-5, IL6, and IL-7) were measured by ELISA in the follicular aspiration fluid obtained during the process of oocyte pick-up (OPU). Results: Among the infertility factor the most common was person factors 45.0% (n=59). The ovarian factor was revealed in 26 (19.8%) of patients, tube factor – in 13 (9.9%), unexplained reason – in 19 (14.5%), gender selection – in 4 (3.1%) and infertility depends on both sides - in 10 (7.6%) of women. According to the results of hysterosalpingogram, tubes were open in 118 (90.1%) of patients, were closed in 13 (9.9%) of all women, involved in the study. The pregnancy outcomes were as following: no transfer –in 7 (5.3%), no pregnancy – in 60 (45.8%), presence of pregnancy – in 56 (42.7%), menstrual cycle cancelled – in 8 (6.1%%) of patients. IL-1? levels were statistically significant different in the follicular aspiration fluid of patients with pregnancy and without pregnancy (p=0.039). Conclusion: There is statistically significant association between IL-1? in follicular aspiration fluid and successful pregnancy in IVF procedure.
Key words: cytokines, IL-1?, pregnancy, in vitro fertilization, follicular aspiration fluid.
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