Full Article: PDF
Scientific Object Identifier: http://s-o-i.org/1.1/TAS-09-65-18
DOI: https://dx.doi.org/10.15863/TAS.2018.09.65.18
Language: English
Citation: Noor S, Ayub M, Iftikhar N (2018) PREVALENCE OF DIFFERENT TYPES OF COLORECTAL CARCINOMAS IN PATIENTS BELOW 40 YEARS AGE. ISJ Theoretical & Applied Science, 09 (65): 118-123. Soi: http://s-o-i.org/1.1/TAS-09-65-18 Doi: https://dx.doi.org/10.15863/TAS.2018.09.65.18 |
Pages: 118-123
Published: 30.09.2018
Abstract: Objective: This study was conducted to determine prevalence of various histological forms of colorectal cancers among the patients having age less than 40 years. Design and Setting: This is a cross sectional study of descriptive type. Study was conducted in Khyber Teaching Hospital Peshawar, Pakistan. Duration of study: Study was started in January 2018 and completed in July 2018 having total duration of 7 months. Patients and Methods: All patients presented in outdoor of the hospital under study during study period with signs and symptoms suggesting colorectal cancer were included in this study. Proper history taken and thorough clinical examination was done. Initially digital rectal examination was performed followed by proctoscopy, sigmoidoscopy, colonoscopy, ultrasound abdomen, CT scan abdomen with contrast. In which patient’s tumor was suspected biopsy was taken and sent for histopathology. All important points of history and positive findings on clinical examination and investigations were documented properly. An inclusion and exclusion criterion was established according to which only those cases were included having age below 40 years, newly diagnosed cases, having no associated chronic disease and not operated previously for colorectal cancer. After establishing diagnosis staging workup was done. Some of the patients were referred to other institutions after establishing diagnosis and taking all necessary data for study. Treatment option was selected depending on the extent of tumor size and metastasis. TNM and Dukes systems were used for staging tumor. Data was analyzed on Microsoft office version 2012 and statistical softwares. Results presented in the form of table and figures. Results: Total 136 cases were diagnosed with colorectal cancer and out of them 60 cases were below 40 years and above 15 years of age with mean age +-SD of 28+-11.5 years. Various diagnostic techniques were used in these cases such as proctoscopy in 35% cases, digital rectal examination in 28.3%, sigmoidoscopy in 34%, colonoscopy in 25%, barium enema done in 25%, USG abdomen in 31.7%, CT scan abdomen in 8.3% and exploratory laparotomy was performed in 3.3% cases. There were 61% male and 39% were female cases. Different tumor positions were seen in study subjects in 50% cases rectum was involved, in 11.7% rectosigmoid junction, 1.7% descending colon and 3% splenic flexure was involved. There were 68% cases with tumor in left colon. In 32% cases right side tumor present including 16.7% in caecum, 3.3% transverse colon, 8.3% hepatic flxure and 3.3% ascending colon.bIn 85% cases adenocarcinoma was diagnosed on histopathology. In 3.3% carcinoid tumor, in 8.3% lymphoma and juvenile polyposis coli was present in 3.3% cases. Conclusion: Colorectal carcinoma mostly involves left side colon with most common histological type of adenocarcinoma non-mucinous type. It has significance incidence in young age people below 40 years.
Key words: Colorectal cancer, adenocarcinom colon, prevalence of colonic cancer
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