Pages: 124-128
Published: 30.09.2018
Abstract: In this paper, are presented the results of changes in the parameters of the pancreatobiliary system after the therapy with cofosbuvir / lepidasvir in patients with hepatitis C are presented. In the course of treatment, enzyme replacement therapy was also used for patients who were in a period of exacerbation. To this end, was analyzed the blood in 11 patients with hepatitis C without exacerbation and 14 patients in the period of exacerbation. In all patients, were assessed the genotype and viral load of hepatitis C, the concentration of bilirubin, the activity of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), alkaline phosphatase (AFP), ?-amylase, cholinesterase CHE), lactate dehydrogenase (LDH). After the complex treatment in all patients, the viral load was reduced to zero. A significant decrease in the concentration of bilirubin, ALT, AST, LDH, GGT, APP, and ?-amylase in the serum of patients with viral hepatitis C was found, as compared to the results before the treatment. Thus, as can be seen from the obtained results, the combined treatment with preparations of cofosbuvir / lepidasvir suppresses the formation and multiplication of the hepatitis C virus molecules and causes the normalization of disturbances in the pancreatobiliary system.
Key words: hepatitis C, alanine aminotransferase, alkaline phosphatase, gamma-glutamyltransferase, amylase, sophosbuvir / lepidasvir.
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