ISJ Theoretical & Applied Science 01(93) 2021

Philadelphia, USA

Yurchenko, O. I., Chernozhuk, T. V., & Kravchenko, O. A.

Atomic absorption determination of Iron and Magnesium in pharmaceuticals.

Full Article: PDF

Scientific Object Identifier: http://s-o-i.org/1.1/TAS-01-93-33

DOI: https://dx.doi.org/10.15863/TAS.2021.01.93.33

Language: English

Citation: Yurchenko, O. I., Chernozhuk, T. V., & Kravchenko, O. A. (2021). Atomic absorption determination of Iron and Magnesium in pharmaceuticals. ISJ Theoretical & Applied Science, 01 (93), 201-208. Soi: http://s-o-i.org/1.1/TAS-01-93-33 Doi: https://dx.doi.org/10.15863/TAS.2021.01.93.33

Pages: 201-208

Published: 30.01.2021

Abstract: The modern sample preparation of pharmaceuticals by decomposing an organic matrix by ultrasound and Triton X-100 was done. The influence of surfactant concentration and ultrasound treatment time on the sensitivity of Iron and Magnesium determination was studied. It was established that the most significant increase in the sensitivity of the atomic absorption determination of analytes was achieved at ? (Triton X-100) = 3% and ultrasound treatment time of 15 min. It was found out that the sensitivity enhancement for the determination of Magnesium increases by 1.5 and Iron by 1.8 times. The content of Iron and Magnesium in such as medicaments "Analgin," "Caffeine," "Paracetamol" was determined by the atomic absorption method. The correctness of the results of atomic absorption determination of analytes by the "inserted-found" method was checked. It was shown that the systematic error is not significant. The detection limit of Iron ( ?? ?????? =0,014???? / ??) was estimated by the atomic absorption method. It appeared that limit is even lower than that presented in the literature data.

Key words: Iron, Magnesium, atomic-absorption spectroscopy, sample preparation, ultrasound, Triton X-100, metrologic characteristics.