ISJ Theoretical & Applied Science 10(102) 2021

Philadelphia, USA

Salomov, V.B., Teshaev, Sh.Zh., Ochilov, K.R., Fayziyev, Kh.B., & Bafoev, U.V.

Morphological characteristics of the stomach wall after modeling traumatic brain injury in white rats.

Full Article: PDF

Scientific Object Identifier: http://s-o-i.org/1.1/TAS-10-102-82

DOI: https://dx.doi.org/10.15863/TAS.2021.10.102.82

Language: English

Citation: Salomov, V.B., Teshaev, Sh.Zh., Ochilov, K.R., Fayziyev, Kh.B., & Bafoev, U.V. (2021). Morphological characteristics of the stomach wall after modeling traumatic brain injury in white rats. ISJ Theoretical & Applied Science, 10 (102), 768-774. Soi: http://s-o-i.org/1.1/TAS-10-102-82 Doi: https://dx.doi.org/10.15863/TAS.2021.10.102.82

Pages: 768-774

Published: 30.10.2021

Abstract: Relevance of the problem: The article indicates that with traumatic brain injury, the function of the gastrointestinal system is seriously impaired. The lack of literature data on morphological changes in the stomach wall depending on the periods of traumatic brain injury according to the clinical classification is stated and it is confirmed that the restoration of the function of the gastrointestinal system occurs after stabilization of respiratory and hemodynamic disorders Purpose of the research: To study the morphological characteristics of the wall of the stomach in white rats at different periods of traumatic brain injury in the experiment. Materials and research methods. The work was performed on 24 white outbred rats of both sex, weighing about 250-300 grams, 3 months of age. Craniocerebral trauma was caused in white rats by a horizontal frontal shock model of TBI by simulating a road traffic injury. The morphological changes in the wall in white rats were studied depending on the periods of traumatic brain injury. Results of the study: In the acute period, diapedetic hemorrhages and pronounced pericellular edema were observed against the background of microcirculation disorders in the gastric mucosa of white rats. In the second subacute period, the above changes worsened and covered the muscular layer of the stomach. In the third long-term period, lymphocytic infiltration, subatrophic processes, signs of proliferation and tissue regeneration in the stomach wall were determined. Conclusions: It was found that morphological changes in the stomach wall are characteristic in all periods of traumatic brain injury and in proportion to the severity of the injury. These morphological changes occur as a result of a disturbance in the nervous regulation of the stomach against the background of spasm and disturbance of microcirculation in the wall of the stomach of a white rat in response to a traumatic brain injury.

Key words: modeling of traumatic brain injury, white rat, horizontal shock method, morphological changes in the stomach wall.